Linking clotting and autoimmunity

SummaryAntiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by increased risk for arterial, venous and/or microvascular thrombosis and various obstetric complications, including recurrent miscarriages, premature births, and preeclampsia, in association with the persistent presence of autoantibodies targeting phospholipids (aPLs). The clinical spectrum of APS ranges from mild clinical manifestations to the development of a…

Dinitrogen complexation and reduction at low-valent calcium

Calcium catches dinitrogenAlthough lithium reduces dinitrogen, the other alkali and alkaline Earth metals have proven largely inert to the gas under ambient conditions. Rösch et al. report that with just the right β-diketiminate ligand and an assist from potassium as terminal reductant, calcium can mediate dinitrogen reduction. Crystallography and spectroscopic characterization revealed a product in…

Fungi prevent intestinal healing

SummaryChronic intestinal diseases, such as inflammatory bowel disease (IBD), are associated with continual tissue damage that must be repaired. Mucosal restoration is a coordinated process that can be influenced by extrinsic factors, including the commensal bacterial community (1–3). However, individuals with intestinal disease often receive antibiotics during their care, disrupting these beneficial bacteria. Although fungi…

Synthesis of borophane polymorphs through hydrogenation of borophene

Hydrogenating boropheneThe two-dimensional material borophene, which is formed on silver surfaces, has a diverse polymorphism and is predicted to have unusual materials and electronic properties. However, it is highly unstable outside of ultrahigh vacuum conditions and oxidizes readily, which hampers exploration of its properties. Li et al. hydrogenated these materials with atomic hydrogen and showed…

Immunity to SARS-CoV-2 variants of concern

Vaccine candidates based on spike, the glycoprotein that is essential for host cell entry by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were being designed within days of its reported sequence in January 2020. All the vaccines aim to prevent disease primarily (but not exclusively) by eliciting neutralizing antibodies that block spike and therefore prevent…