Last year skinimalism was the headlining beauty trend of 2021. It saw makeup application become more minimal and our focus on beautiful, healthy-looking skin intensify. This year cosmetic treatments will have much the same, um, treatment. 

We’re still in the market for products and procedures that bring the best out of our complexions, but for many, we want to take a more natural and subtle approach, which is perhaps why Biotulin’s Supreme Skin Gel, the serum dubbed “Botox in a bottle,” is firmly back on the map.

The skin-care hero rose to prominence back in 2017, when Michelle Obama’s makeup artist, Carl Ray, let slip that Kate, the Duchess of Cambridge, had recommended it to the then first lady. “Michelle Obama has been using this organic Botox gel regularly on the recommendation of Kate Middleton,” the makeup artist told Celebrities Style magazine. High praise indeed, from two of the world’s most photographed women. It’s also been reported that Kate also spread the word to her sister-in-law Meghan Markle, who was won over by its natural credentials.

And the royal seal of approval doesn’t stop there. Queen Letizia of Spain is also said to be a huge fan, according to her little sister, Telma Ortiz Rocasolano, who told Spanish publication Vida y Estilo that she uses Biotulin as a natural alternative to Botox. “Letizia is already by nature a very beautiful woman. She knows that plastic surgery is something that would only hurt, something you do not need,” Ortiz Rocasolano revealed, adding her sister “completely rejects Botox treatments.”

With such a high-profile fan following, the serum must be next-level, so what’s the deal? It’s said to smooth skin on an organic basis as part of your daily skin-care routine. The main ingredient, spilanthol—a local anesthetic derived from the extract of the Acmella oleracea (or paracress) plant—works by reducing muscle contraction, thereby reducing wrinkles, particularly around the eye area and between the brows. And additional plant extracts help to moisturize and hydrate, alongside hyaluronic acid. It looks like there are receipts too. According to the brand, independent efficacy studies have shown that skin can start to look firmer in as little as an hour.

The good news is that despite its exclusive clientele, the serum is available to pick up on Amazon for around $65. So, if you’re in the market for some smoothing action without any needles involved, this mega serum comes highly recommended. 

This story originally appeared on Glamour U.K. 

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